Opportunities and challenges with animal models for acute radiation syndrome drug discovery

Modern drug discovery technologies: opportunities and challenges in lead discovery.

The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have revitalized the screening process model and emphasized the importance of exploring the intrinsic complementary nature of classical and modern methods in drug research. In this cont...

Drug discovery and development for ageing: opportunities and challenges.

The prevention and treatment of late-life dysfunction are the goals of most geriatricians and should be the primary target for discovery and development of new medicines for elderly people. However, the development of new medicines for elderly people will face a number of challenges that are not seen for other patient populations. The burdens of multiple chronic diseases, low physiological rese...

Multiprotein Systems As Targets for Drug Discovery: Opportunities and Challenges

In the past twenty years structural biology has come to play a major role in lead optimization and target identification in the process of drug discovery. Only recently, however, has the development of highthroughput methods of structure determination provided a powerful approach to the screening of fragment binding so that structural biology can now contribute directly to lead discovery. Most ...

2 GPCRs : new opportunities and challenges for drug discovery

Recent Advances in Antimalarial Drug Discovery — Challenges and Opportunities

Malaria drug discovery is a challenging and difficult task due to the unavailability of the vaccine and lack of newer drugs. The most potent artemisinin and its deriva‐ tives, widely used in combination therapies for curing malaria worldwide are also now falling to resistance in some parts of the world. Thus, to combat malaria, new drugs possessing high therapeutic value, minimal toxicity, rapi...